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Doctoral Fellowships


Development of a decellularised pericardium percutaneous heart valve (ESR7)

  

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The aim of this Fellowship is to develop a percutaneous heart valve (PHV), using decellularised porcine or bovine pericardium, which can be delivered to the patient either unseeded, or seeded with the patient’s own cells in vitro and conditioned in a bioreactor prior to implantation. The work will initially focus on the development of a collapsible stent, which can be compressed to a small enough diameter, in order to be inserted into a vein, and then expanded to its final diameter at the required valve position. Pericardia will be decellularised according to previously established protocols, and will be assessed against native pericardium in terms of histology, biochemistry, cytotoxicity and biomechanics. The durability and calcification potential of the scaffolds will be assessed in other ESR projects within TECAS‐ITN. Trileaflet PHVs will be manufactured by mounting the pericardial scaffolds to the developed stents, and their function will be assessed hydrodynamically. PHVs will be seeded statically with stem cells to identify the most favourable seeding conditions, and optimally‐ seeded PHVs will be conditioned in a bioreactor under different conditions to optimise valve regeneration. Statically‐seeded and conditioned PHVs will be assessed in terms of cell phenotype, structural/biomechanical integrity and neo‐matrix synthesisto assessthe effect of conditioning on valve regeneration.

 

 

 

Research Field: Cardiovascular tissue engineering and regenerative medicine

  

Collaborators: Hannover Medical School, RWTH Aachen University and Hospital, University of Patras, Eindhoven University of Technology

 

Supervision: Prof. Gino Gerosa (PI), Dr. Filippo Naso (co‐I), Dr. Laura Iop (co‐I), Dr. Sotirios Korossis (co‐I), Prof. Stefan Jockenhövel (co‐I), Prof.Demosthenes Mavrilas(co‐I), Prof. Frank Baaijens(co‐I)



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EVENTS

TECAS-ITN End-of-Network Conference

 Padua, November 28-30, 2016

The TECAS-ITN European Doctoral Academy in Regenerative Engineering, is organising the End-of-Network Conference in Padua, Italy.


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