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Doctoral Fellowships

Molecular biomechanics of α-actin remodelling (ESR1)




The aim of this Fellowship will be to investigate whether the cellular traction that develops, together with the anisotropic extracellular matrix micro-environment, can predict collagen architecture in TE constructs and native tissues. The Fellow will develop 2D and 3D mathematical descriptions of intracellular α-actin distribution and orientation in response to mechanical stimuli and will implement these constitutive modelsin a molecular biomechanics 3D finite element computational model. The computational predictions of α-actin distribution and orientation will be validated against experimental models, and will be subsequently included in  an established cell-based computational model of collagen remodelling. The predictions of the combined computational model of α-actin and collagen remodelling will be validated against experimental TE model systems developed in other projects within the TECAS-ITN.




Research Field: Cardiovascular tissue engineering and regenerative medicine


Collaborators: RWTH Aachen University and Hospital, Hannover Medical School, University of Padua.


Supervision: Prof. Frank Baaijens (PI), Prof. Carlijn Bouten (co-I), Dr. Sotirios Korossis (co-I), Prof. Stefan Jockenhövel (co-I), Prof. Gino Gerosa (co-I)


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TECAS-ITN End-of-Network Conference

 Padua, November 28-30, 2016

The TECAS-ITN European Doctoral Academy in Regenerative Engineering, is organising the End-of-Network Conference in Padua, Italy.

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