Member Login

 
Untitled Document
Untitled Document

Doctoral Fellowships


Molecular biomechanics of α-actin remodelling (ESR1)

 

Description:

 

The aim of this Fellowship will be to investigate whether the cellular traction that develops, together with the anisotropic extracellular matrix micro-environment, can predict collagen architecture in TE constructs and native tissues. The Fellow will develop 2D and 3D mathematical descriptions of intracellular α-actin distribution and orientation in response to mechanical stimuli and will implement these constitutive modelsin a molecular biomechanics 3D finite element computational model. The computational predictions of α-actin distribution and orientation will be validated against experimental models, and will be subsequently included in  an established cell-based computational model of collagen remodelling. The predictions of the combined computational model of α-actin and collagen remodelling will be validated against experimental TE model systems developed in other projects within the TECAS-ITN.

 

 

 

Research Field: Cardiovascular tissue engineering and regenerative medicine

 

Collaborators: RWTH Aachen University and Hospital, Hannover Medical School, University of Padua.

 

Supervision: Prof. Frank Baaijens (PI), Prof. Carlijn Bouten (co-I), Dr. Sotirios Korossis (co-I), Prof. Stefan Jockenhövel (co-I), Prof. Gino Gerosa (co-I)

 


« Go back to Doctoral Fellowships page
Untitled Document

EVENTS

TECAS-ITN End-of-Network Conference

 Padua, November 28-30, 2016

The TECAS-ITN European Doctoral Academy in Regenerative Engineering, is organising the End-of-Network Conference in Padua, Italy.


read more
Demo

LATEST VIDEO