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Hannover Medical School

Hannover Medical School

The Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO) is the main research facility of the Department of cardiothoracic, Transplantation and Vascular Surgery (HTTG) of Hannover Medical School (MHH), and focuses on stem cell, tissue engineering and biohybrid lung research.

 

HTTG is one of Europe’s leading research intensive surgical clinics and has a long history in lung transplantation, currently being the largest lung transplantation centre in Europe and amongst the three leading lung transplantation centres worldwide. LEBAO is engaged in active training and teaching at u/g, p/g and postdoctoral levels, and currently hosts 50 doctoral and 40 postdoctoral researchers and 15 technicians. LEBAO’s research income in 2011 exceeded €1.3M, whereas it has close collaborations with the Competence Centre for Cardiovascular Implants (Medimplant) and Corlife GmbH.

 

 

LEBAO leads the DFG funded cluster of excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy) focusing on the regeneration of blood, heart, lung and liver. REBIRTH receives an annual financial support of €6.78M and integrates MHH, University of Hannover, Laser Centre Hannover, University of Veterinary Medicine Hannover, and major German federal networks (Max Planck Institute for Molecular Biomedicine, Fraunhofer Institute of Toxicology & Experimental Medicine, Friedrich-Loeffler Institute and Helmholtz Centre for Infection Research).

 

REBIRTH funds the interdisciplinary PhD Programme Regenerative Sciences, which is administered by the Hannover Biomedical Research School (HBRS; Graduate School of Excellence) part of MHH, which also administers 2 additional PhD Programmes (Molecular Medicine, Infection Biology). MHH also participates in the MULTISCALEHUMAN ITN led by University of Geneva, and leads the Stem and Progenitor Cells in Clinical Medicine International Graduate School programme and the European Research Training Group “Pseudomonas”, to which LEBAO is a participant. 

 

LEBAO awards degrees through HBRS, which offers transferable skills and MSc level courses designed for its 3 PhD Programmes, which are also available to the TECAS ITN Fellows. MSc level courses include biomedicine, medical imaging, biochemistry, biomedical engineering, molecular biology, cardiovascular biomechanics, stem cell biology, statistics, cell imaging, bionanotechnology, biomaterials, immunology & microbiology. Transferable skill courses include quality assurance and regulation, good manufacturing practice (GMP), healthcare economics, research ethics, writing and interpreting scientific documents, finding & managing information for your PhD and presentation skills. Further practical courses available for the Fellows at LEBAO include, high resolution imaging (FEGSEM, TEM), biomechanical simulation systems, valve bioreactor, fatigue testing of heart valves, biomechanical characterisation of tissues, histological and immunohistological staining techniques, cell culture and microscopy techniques, MR imaging, animal care, large animal models (sheep, pig), PCR, ELISA, TUNNEL assay, biocompatibility assays, peptide functionalisation, biochemical techniques, DNA assays, MSC characterisation, valve hydrodynamics, and decellularisation techniques.

 

LEBAO also organises weekly seminars and special lectures in the field of regenerative medicine open to all postgraduate students. The Fellows will have access to a range of complementary skill courses offered by the MHH Personnel Development Office, including languages (German, English, Dutch, French; in collaboration with University of Hannover), project management, business development, public and commercial awareness, public engagement, team working, grant writing, intellectual property rights, enterprise and KT, marketing for researchers, commercial skills for life scientists, leadership for research staff, computing skills, leading and managing in an academic environment, supervising MSc students, event organisation, presentation techniques, dealing with the media, TV interview skills, writing press releases, and outreach activities

RWTH Aachen University

 

RWTH Aachen University

 

The Helmholtz Institute for Biomedical Engineering at RWTH Aachen University assumes top position in Germany within the Excellence Initiative of the German Federal & State governments. The Helmholtz Institute for Biomedical Engineering acts as a cross-faculty platform of the RWTH Aachen University, being sustained by the Medical Faculty, the Faculty of Electrical Engineering and Information Technology, the Faculty of Mechanical Engineering, and the Faculty of Mathematics, Computer Sciences and Natural Sciences.

The Institute of Applied Medical Engineering (AME) is part of the Helmholtz Institute and focuses on research in the areas of cardiovascular engineering, cardiovascular tissue engineering, rehabilitation and prevention engineering, biophysical and education engineering, and experimental medicine and immune therapy. AME has close cooperation with clinical partners through it affiliations to the Medical Faculty and Aachen University Hospital.

 

It has also a close collaboration with 3T GmbH on the commercial exploitation of textile scaffolds for tissue engineering. AME involves 120 academics, postdoctoral fellows and PhDs, and 6 technicians.  

 

The Cardiovascular Tissue Engineering Group (CTEG) consists of 13 academics, postdoctoral and PhD researchers.AME is intensively involved in the interdisciplinary teaching and training of numerous u/g and p/g level students. It runs a 2-year MSc in biomedical engineering programme (instruction in English), and the DFG-funded BioInterface graduate programme. MSc level courses, which would be also available to the TECAS ITN Fellows, include musculoskeletal system, cardiovascular system, radiology, introduction to medicine for scientists and engineers 1 & 2, basics of natural sciences, basic electrical engineering, medical imaging for scientists and engineers, interventional radiology: image guided surgery without a scalpel, image guided therapy, molecular imaging, immunology, electrophysiology and instrumentation, measurement technology, artificial organs 1 & 2, tissue engineering, biomedical technology, and biomedicine practical course. Practical courses available for the TECAS Fellows at AME include, histological and immunohistological staining techniques, biochemical techniques, biomechanical characterisation, valve hydrodynamic assessment, fibrin scaffold fabrication, DNA assays, valve bioreactor, MTT, PCR, ELISA, TUNEL assay, cell culture and microscopy techniques, high resolution imaging, animal care, and large animal models (sheep).  

 

Moreover, AME runs summer schools of the IDEA League (Imperial College London, TU Delft, ETH Zurich, RWTH Aachen, ParisTech), and a number of seminars, including seminar on cell biology, joint laboratory seminar, physiology seminar for medical students, seminar immunotherapy, colloquium on biomedical engineering and related fields, physiology symposium on current research topics, seminar for internship, GMP seminar, seminar on presentation techniques, how to read a paper, and seminar on learning techniques.

 

The TECAS Fellows will also have access to the courses delivered by the Centre for Doctoral Studies and Career Centre of RWTH Aachen University. The Centre for Doctoral Studies in collaboration with the Career Centre supports the development of research skills and research careers of PhD students by offering a range of transferable and complementary skills training to which Network fellows would also have access. This includes managing your research degree, planning and managing research, effective teaching and supervision, personnel and project management, intercultural management and communication, presenting and publishing research, presentation techniques, rhetoric, time management, research career development, interacting with media and public relations, intellectual property rights, research ethics, research methodology, e-learning, research grant and scientific writing, public awareness & engagement, writing for non scientific press, and event organisation. The TECAS Fellows will also be offered language courses on different levels in German, French and Dutch.

Eindhoven University of Technology

 

Eindhoven University of Technology

 

 

 

The Soft Tissue Biomechanics and Tissue Engineering group at the Department of Biomedical Engineering of the Eindhoven University of Technology is structured around 5 senior scientists, who collectively hold expertise in cardiovascular and muscle tissue engineering, computational biomechanics and soft tissue biomechanics. The team is complemented by 16 MSc and 22 PhD students, 6 postdoctoral researchers, and 5 technicians. 

 

The group has a close collaboration with the Surgical Research Department and Cardiovascular Surgery Clinic of the University Hospital Zurich headed by Prof Dr. med Simon P. Hoerstrup. The Department of Biomedical Engineering has 3 programmes including a BSc programme in biomedical technology and the two MSc programmes in Biomedical Engineering and Medical Engineering. The engineering courses are taught by Eindhoven, whereas the biological and medical courses are taught in collaboration with the Departments of Health Sciences and Medicine of the University of Maastricht. MSc level modules available to the TECAS Fellows include molecular bioengineering, molecular imaging, biomedical imaging and modelling, radiology, surgery, radiotherapy, cardiology, cell and tissue mechanics and engineering, cardiac mechanics, haemodynamics, biofluid mechanics and dynamics, computer-aided diagnosis, modelling of biomembranes and cardiac muscle, drug delivery systems, scaffolds for tissue engineering, structure-activity relationships of drugs, MR imaging of arteriosclerosis.

 

Further courses relevant to the network include mathematical models in physiology, systems biology, bio-electricity, measuring and monitoring of vital functions, electrophysiological measurements in medicine, measurements on respiration and circulation, fundamental of biostatistics, new developments in fluorescence microscopy on living tissues, biosensors for medical diagnostics, biomaterials, computational physics, physical transport phenomena, cardiac modelling, vascular biology, NMR/MRI, multi-scale image analysis. Practical courses available to the TECAS Fellows include basic cell culture, histology and immunohistochemistry techniques, DNA assays, MTT, ELISA, biomechanical and hydrodynamic characterisation of valves, biochemical techniques, high resolution imaging, and microscopy techniques. Complementary skill p/g courses include time management, IT courses, supervising MSc students, presenting your research, enhancing your impact, writing English for publication, presenting in English, intellectual property and valorisation, engaging the public with science, career development, medical ethics, project based management, technical writing and editing, project management, presentation skills, and professional development.

 

Moreover, a range of language courses will be available for the Fellows, including, Dutch, English, and German. Eindhoven University of Technology are partners with the University of Tilburg in the Brabant Centre of Entrepreneurship. The Centre will offer to Network Fellows training on entrepreneurship skills.

University of Padua

University of Padua

 

The Cardiac Surgery Unit (CSU) is part of the Department of Cardiac, Thoracic and Vascular Sciences (CTVS) in PaduaUniversityHospital at the University of Padua. CSU is in close collaboration with the Departments of Veterinary Clinical Sciences, Experimental Biomedical Sciences, Medical Diagnostic & Special Therapies, and Chemical Engineering Processes. The Cardiac Surgery Unit (CSU) is part of the Department of Cardiac, Thoracic and Vascular Sciences (CTVS) in PaduaUniversityHospital at the University of Padua. CSU is in close collaboration with the Departments of Veterinary Clinical Sciences, Experimental Biomedical Sciences, Medical Diagnostic & Special Therapies, and Chemical Engineering Processes.

CSU have a current portfolio of 14 research projects on hearts valves and myocardium. Over the last 6 years the CTVS has won several Italian grants including the Biotech II and III, a Regione Veneto fund and numerous University of Padua research grants and fellowships. CSU has also active collaborations with St. Jude Medical (USA) and Fidia Pharmaceutics (Italy). CSU involves 20 clinicians and academics, 6 postdoctoral researchers, and 10 PhD, 5 MD and 5 MSc students.

 

CSU has access to a range of facilities and laboratories, the main of which are a hydrodynamic and biomechanical suite and fully equipped large animal operation room. CTVS runs a Doctorate programme in cardiovascular sciences and a MSc programme in cardiovascular pathology. Students and scientists come from interdisciplinary fields such as biomedical engineering, medicine and surgery, biology and health biotechnology. CSU has gained substantial expertise in organising clinical research projects on heart valves and has an excellent track record on the clinical translation of technologies for cardiovascular surgery. CSU has also developed a substantial experience on the transplantation of heart valves and cardiovascular patches.

 

The TECAS Fellows will have access to the MSc level courses designed for the Doctorate and MSc programmes. These include biomechanics, biometric and morphologic analysis of heart valves, bioreactor technology, synthetic peptides design, in vitro characterisation of cardiovascular tissues. Additional courses and seminars available to the Fellows and delivered by the Padua Medical School include clinical pathology, forensic pathology, endomyocardic biopsying, cardiac transplantation, congenital cardiopathies, organs transplants, paediatric cardiology, pulmonary and cardiovascular molecular pathology, surgical cardiovascular pathology, and rare cardiovascular pathology. CSU also organises summer schools on cardiovascular sciences.

 

Practical courses available to the Network Fellows include tissue decellularisation protocols, large animal models, biomechanical characterisation of cardiovascular tissues, hydrodynamic assessment of heart valves, cell culture, histology and immunohistochemistry techniques, DNA assays, MTT, ELISA, biochemical techniques, biocompatibility assays, and microscopy techniques. Moreover, a range of language transferable and complementary skills courses will be available to the Fellows including, beginners, intermediate and advanced Italian, English and German, medical ethics, GMP training, tissue banking, scientific writing, statistics, giving effective presentations, IP rights, public awareness and engagement, and writing for non scientific press.

University of Patras

 

University of Patras

 

The Laboratory of Biomechanics and Biomedical Engineering (LBBE) in the Department of Mechanical Engineering and Aeronautics at the University of Patras is an integrated group of engineers, chemists, physicists, and clinicians. The group activities extend to the Departments of Chemical Engineering, Medicine, and Cardiothoracic Surgery, and specialises in cardiovascular, orthopaedic and cell biomechanics, cell-biomaterial interactions, protein absorption, haemocompatibility, and calcification models. LBBE has a fully equipped large animal operation room. The group comprises 8 academics and 3 technicians, who engage with the multidisciplinary teaching and training of u/g and p/g students and postdoctoral fellows. Currently, the group is complemented by 11 PhDs, 4 postdoctoral researchers, 5 MSc students and 6 u/g project students. The group has graduated 8 PhDs in last 4 years; 25 PhDs in last 10 years.

 

The Department of Mechanical Engineering and Aeronautics runs a BEng and an MSc programme on biomedical engineering, which are taught jointly with the Department of Medicine. The Network Fellows will have access to these courses, which include basic principles of extracorporeal circulation, introduction to trachiobronchial and lung physiology, mechanical and biological heart valves, biomechanics, biomaterials, and artificial organs. Practical coursed offered to the Fellows include mechanical testing, chemical analysis and crystal identification, spectral analysis (FTIR, atomic absorption), techniques in microscopy (AFM, SEM, confocal), stoichiometric analysis, mass spectrometry, and basic histological techniques.

 

Complementary and transferable skills courses will be offered to the Fellows in collaboration with the Career Advisory Office, Centre of Vocational Training, Intercultural Education Centre, and Foreign Languages Teaching Unit of the University of Patras. These will  include introductory courses to Greek language for foreign students, English language, scientific and technical writing, managing information for PhDs, student supervision, teaching practice, media and public engagement, presentation skills, event organisation, writing for non scientific press, research ethics, managing IP, statistics, IT skills, project and management, and leadership skills.

Corlife GbR

Corlife GbR

Corlife GbR was founded in 2008 to commercialise innovative tissue engineering technologies and is dedicated to the development of clinical solutions to address the chronic shortfalls in donor tissue availability. The company develops and supplies products and technologies for cardiovascular and cardiothoracic surgery. Corlife is specialised in stented and stentless devices based on TE scaffold composites, which integrate into the patient's body and become indistinguishable from the patient's own tissue.The underpinning science was developed in LEBAO. The company has exclusive rights over several technologies in regenerative TE.

 

Corlife is led by a team of experienced commercial and technical specialists, and they are in partnership with LEBAO, utilising additional research and training facilities in MHH and University of Hannover. Corlife employs 10 clinicians, engineers, biologists and industrialists. The company has been engaged with the multidisciplinary training of postdoctoral researchers in clinical & commercial translation of cardiovascular tissue-engineered implants since its establishment.

The company conducts research and development in a quality-controlled setting according to EN ISO 13485 and GMP. It also delivers weekly seminars and special lectures at MHH in the field of RM open to all students and PhDs. Corlife-hosted Fellows will have access to all courses offered by Hanover. Degrees will be offered though the Hannover Biomedical Research School.

 

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EVENTS

TECAS-ITN End-of-Network Conference

 Padua, November 28-30, 2016

The TECAS-ITN European Doctoral Academy in Regenerative Engineering, is organising the End-of-Network Conference in Padua, Italy.


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